New publication: Hepatic and renal improvements with FXR agonist Vonafexor in individuals with suspected fibrotic NASH

Published on 29/12/2022

ENYO Pharma is proud to share the publication of the results from our Phase 2 LIVIFY study with Vonafexor in NASH patients in Journal of Hepatology.

This article describes the remarkable effects of Vonafexor after only 12 weeks of treatment in these patients: strong liver fat reduction, weight loss, liver enzyme improvements …., and last but not least renal function recovery. These strongly differentiated fibrolytic and anti-inflammatory effects of Vonafexor compared to other FXR agonists correlate very well with those observed in several preclinical models of severe CKD and rare kidney diseases like Alport Syndrome. All these results led us to pursue the development of Vonafexor in several rare and more common diseases of the kidney/liver axis.
Publication here

Read next in 'Latest news'

• Orphan Drug Designation (ODD) granted to Vonafexor for Alport syndrome by both the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA)
• New publication : An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
• Swiss NASH Foundation sponsorship
• ENYO Pharma in the Top 50 of the EIC ScalingUp List
• Selection in the Best of the Liver Meeting 2021